Low natural levels of lithium in the brain may play a role in Alzheimer’s disease, according to new research from Harvard Medical School. Lithium, a mineral that helps protect brain cells, regulate mood, and support memory, has long been used to treat bipolar disorder and depression. Now, scientists believe it could also help shield the brain from Alzheimer’s-related damage.
Researchers studied mice, human brain tissue, and blood samples from people with varying cognitive health. They found that lithium levels dropped as Alzheimer’s symptoms worsened. In mice, a lithium-poor diet sped up brain aging, increased amyloid plaque buildup, and led to memory loss. A form called lithium orotate, which did not stick to harmful proteins, was able to restore memory and repair brain damage in mice.
Experts caution that more research is needed before lithium can be used as a treatment for Alzheimer’s. If proven effective, simple blood tests could one day measure lithium levels to identify those at higher risk—paving the way for earlier prevention or intervention.
SOURCE:
Source: Original Article
Publish Date: 2025-08-11 06:00:00